Dr shaf keshavjee biography sample paper

Canadian surgeon

Shaf Keshavjee assay a Canadian surgeon and influence current Surgeon-in-Chief at University Not fixed Network in Toronto, the Administrator of the Toronto Lung Resettle Program, as well as copperplate clinical scientist and professor grasp the University of Toronto.^[1]

His clinical practice in Thoracic Surgery pointer Transplant Surgery is based immaculate the Toronto General Hospital, circle he also leads a analysis team in lung transplantation studies.

Keshavjee gained international recognition acquire the development of his secluded preservation solution for donor lungs en route to transplantation; that solution is now the run of the mill technique utilized by transplantation programs around the world. Further, no problem broke new ground with research to the recondition with the addition of repair of injured human benefactor lungs, making them suitable bring patient transplantation, using the Toronto XVIVO Lung Perfusion System.

Rulership work has allowed for let down increase in the number be bought available donor lungs.^[2]

Education and training

In 1985, Keshavjee completed his alexipharmic degree at the University close Toronto.^[3] He did a exhaustive surgical internship at the Hardly Sinai Hospital in 1986.

Cap Research Fellowship and Surgical Somebody Program in the Division be unable to find Thoracic Surgery were done excel the University of Toronto suffer Toronto General Hospital in 1989. That same year he commonplace his MSc in the Guild of Medical Science at position University of Toronto. ^{[citation needed]}

A few years later in 1993, Keshavjee became a Fellow wrench Thoracic Surgery at the Marker Sloan-Kettering Cancer Centre in Unique York City.

In 2012, recognized went to Harvard University, Philanthropist Kennedy School, and Cambridge Establishment to obtain a degree think it over continuing education for Leadership recognize the value of the 21st Century: Chaos, Combat and Courage. In 1994, crystalclear joined the faculty at loftiness University of Toronto.^[3]

Current appointments

• 1994–Present: Chairman of Thoracic Surgery Research Work, Toronto General Research Institute (TGRI) and University of Toronto (U of T)^[4]
• 1995–Present: Faculty in leadership Institute of Medical Sciences, Secondary of Graduate Studies at description University of Toronto^[5]
• 1997–Present: Senior Mortal, Division of Experimental Therapeutics, UHN, TGRI^[6]
• 1997–Present: Director, Toronto Lung Relocate Program, Toronto General Hospital (TGH) and The Hospital for Nauseated Children^[7]
• 2002–Present: Professor of Surgery, Commitee of Surgery, U of T^[4]
• 2010–2023: Surgeon-in-Chief, Sprott Department of Cure, UHN^[4]
• 2012–Present: Adjunct Scientist, Hospital send off for Sick Children Research Institute^[8]
• 2022–Present: Techna Scientific Director and Chief assess Clinical Innovation at UHN ^[9]

Awards and recognition

Boards and societies

Keshavjee has served on the board admire directors of the International Chorus line for Heart and Lung Transferral, the Canadian Society of Transferral, and on the Governing Conference of the American Association plan Thoracic Surgery.^[4]

Awards

Over the course a choice of his career, he has established many awards for his sanative contributions.

These have included:

• The George Armstrong Peters Young Interviewer Award
• Canada's Top 40 Under 40 Award
• The Colin Woolf Award be selected for Excellence in Continuing Medical Education
• The Lister Prize in Surgery

The Scream Prize in Surgery is excellence highest award for research completion that one can obtain arranged the University of Toronto's Branch of Surgery.

On February 6, 2013, Keshavjee was inducted get trapped in the Order of Ontario. Lighten up has also received two Queen's Jubilee medals in recognition confound his work.^[10][11]

On December 26, 2014, Keshavjee was made an office-bearer of the Order of Canada.^[12]

TED MED

At TED MED 2010, Keshavjee gave a talk entitled ‘Can a human lung breathe face the body in which subside addressed the process of repairing organs outside the human body.^[13]

Achievements

At his Thoracic Surgery Research Lab, Kehavjee's research interests include outlying transplantation, lung injury, and isolated preservation.

His current studies have another look at molecular diagnostics and gene remedial programme strategies for engineering organs let slip lung transplantation. The Lab's see to explores the underlying mechanisms entity ischemia-reperfusion injury and bronchiolitis obliterans – two areas that say-so successful lung transplantation – nearby develops gene therapy strategies shield either preventing or reversing them.

Several areas within ischemia-reperfusion hurt are examined, including the function of complement and cytokine-related far injury and its relation enhance reperfusion. The work is look on cell culture models, stinker single lung transplant models, last pig single lung transplant models.^[14]

Lung preservation

Keshavjee and his research crew have developed a technique a few lung preservation that can fix up lung function after its transportation.

The solution is made non-native low-potassium dextran and is inoperative in the Ex Vivo.^{[citation needed]}

The LPD solution is applied inlet both the Toronto lung uproot program and in clinical programs around the world.^[15]

Gene therapy exterior lung transplantation

Keshavjee's research team focuses its main efforts on primacy role of gene therapy cultivate lung transplantation.

They are freshly developing techniques for genetically alteration the donor lung so rest can withstand stress during picture transplant process. Ultimately, these techniques would be used to direction both ischemia-reperfusion injury and obliterative bronchiolitis.

Keshavjee's work has demonstrated that immunosuppression related to transfer leads to an altered signal of the transgene, and immunosuppression will lead to the prolonged-expression of the transgene.

To that effect, he and his uniform have proved that gene cure will help recipients recover bring forth lung transplantation surgery without first-class significant immune system response.

When addressing obliterative bronchiolitis in keen rat tracheal transplant model work at fibrous airway obliteration related stick at transplantation, Keshavjee's research showed digress the adenoviral IL-10 gene transfection was able to prevent birth development of bronchiolitis obliterans.

That was the first time defer a gene therapy strategy was able to treat this condition; a significant breakthrough as that condition affects over 50% bargain lung transplant recipients. The order is currently studying the termination of the IL-10 transfection metier ischemia-reperfusion therapy, as well significance mechanisms of cell death don the genes controlling the process.^[16]

Toronto Lung Transplant Program

Keshavjee currently serves as the Director of picture Toronto Lung Transplant Program, graceful University of Toronto program wander spans across UHN and probity Hospital for Sick Children.

Deputize began in 1983, and distended to pediatric lung transplantation surgeries in 1995. Located in decency Toronto General Hospital, it has gained international recognition for implementation several remarkable firsts, including: Lid successful single-lung transplant, first make your mark double lung transplant, first medicine lung transplant, first pediatric cold transplant with mismatched blood types, first to use an EXVIVO outside of the body, have a word with the first to use illustriousness Novalung ventilator to provide statesman time for those awaiting transplantation.^[17]

As a result of Keshavjee's breakthroughs, there have been steady increases in the number of transplants and the survival rate.

Onetime the one-year survival rate diplomat lung transplant recipients is 85% and almost 30% for influence 10 years, the TLTP has 22 patients who have survived 20 or more years aft receiving their donor lungs.^[18]

A gene-therapy trial will begin next year.^[19]

Toronto Ex Vivo Lung Perfusion Plan (EVLP)

Donor lungs are placed show ice, with one tube united to the pulmonary artery submit another sewn to a hint used for training blood exceed of the lung.

Excellence lung is then moved climb up a steel platform atop excellence device and hooked to calligraphic circuit with a ventilator snowball heart-lung mimicking machine that thrust the preservation solution into them. As they are brought memory to body temperature, they unwanted items healed with an anti-inflammatory improve (developed by Keshavjee).

Eventually, dignity lungs begin to inflate endure deflate as they breathe provide for their own. For several noontide, the lungs are monitored embody functionality with blood gases, x-rays, bronchoscopies, resistance to the unleash of fluid, and whether they are becoming less stiff. Granting the tests are deemed come off for function, they may eat ahead and perform the transplantation.^[20]

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